Space Shuttle Mission Cards were produced from 1996–1999 by United Space Alliance in cooperation with NASA, Space Flight Awareness, and Planet 10. The series was distributed in ten-card sets for each Space Shuttle mission from STS-76 to STS-96, with the exception of STS-92 from 2000. Each Space Shuttle Mission Cards set includes a mission header card and an individual profile card for each crew member.

The Space Shuttle Mission Cards were limited in distribution to educational institutions and space advocacy programs. Various sets are held in the collection of the Smithsonian National Air and Space Museum. NASA and Space Flight Awareness later produced trading cards for International Space Station expeditions.